AT-03 Demonstrated Pan-amyloid Binding and Stimulated the Removal of Amyloid Deposits through Macrophage-Mediated Phagocytosis

Sep 7, 2022 Posters & Publications

AUTHORS: Christophe Sirac1, Roussine Codo1, Arnaud Jaccard1, Sébastien Bender1, Gemma Martinez Rivas1, Frank Bridoux2, Michael Klein3, Gregory Bell3, Spencer Guthrie3, Suganya Selvarajah3, Stephen J. Kennel4, Angela D. Williams4, James S. Foster4, Jonathan S. Wall4 1...

Attralus Announces New Preclinical Data Demonstrating Novel Human Chimeric Antigen Receptor-Macrophages (CAR-M) for Potential Amyloid Removal at 18th International Symposium on Amyloidosis

Sep 6, 2022 Press Releases

PDF Version Human CAR-M cells can be generated with the pan-amyloid reactive p5 peptide as the target amyloid recognition element This novel system may serve as an adjunct to anti-amyloid monoclonal antibodies for the enhanced clearance of tissue amyloid SAN...

Attralus Presents In Vivo Preclinical Data for AT-02 Demonstrating Significant Amyloid Reduction at 18th International Symposium on Amyloidosis

Sep 6, 2022 Press Releases

PDF Version AT-02 demonstrates amyloid reduction from the heart, kidney, liver, and spleen AT-02 induces in vivo macrophage-mediated phagocytosis of amyloid fibrils AT-02 binds potently to multiple types of amyloid including ATTR, AL, and ALECT2 SAN FRANCISCO, Calif....

Detection of extracardiac amyloid in patients with ATTR amyloidosis by PET/CT imaging using the amyloidophilic radiotracer 124I-AT-01 (124I-p5+14)

Sep 6, 2022 Posters & Publications

AUTHORS: Wall, Jonathan1, Kennel, Stephen J1, Stuckey, Alan1, Powell, Dustin2, Guthrie, Spencer3, Martin, Emily1 1 University of Tennessee Graduate School of Medicine, USA 2 University of Tennessee Medical Center, USA 3 Attralus, Inc., USA Click Here to View...

A kit method for direct radiolabeling the amyloid reactive peptide p5+14 with technetium-99m (99mTc) for the detection of cardiac amyloidosis by SPECT/CTimaging

Sep 6, 2022 Posters & Publications

AUTHORS: Kennel, Stephen J, Jackson, Joseph W, Stuckey, Alan C, Richey, Tina, Wall, Jonathan University of Tennessee Graduate School of Medicine, USA Click Here to View...