Attralus Announces New Clinical Data in ATTR CM and AL With AT-01 (Iodine (I-124) Evuzamitide), a Novel Amyloid-Specific Imaging Agent

Sep 12, 2022 Press Releases

PDF Version AT-01 shows increased LV uptake and LV amyloid activity in all cardiac ATTR and AL subjects, but in none of the controls (100% accuracy) AT-01 demonstrates significantly higher left ventricular uptake in ATTR-CMP participants than florbetapir SAN...

Attralus Announces Presentation of Clinical Data for AT-01 (Iodine (I-124) Evuzamitide), a Novel Amyloid-Specific Imaging Agent, at the 18th International Symposium on Amyloidosis

Sep 8, 2022 Press Releases

PDF Version AT-01 is a first-in-class pan-amyloid imaging agent capable of detecting diverse types of systemic amyloidosis in multiple organs Sensitivity in those with previously diagnosed cardiac disease was 100% in ATTR and 93% in AL Organ-specific changes in...

Attralus Presents Preclinical Data Demonstrating Potent Binding to All Types of Systemic and Cerebral Amyloid by its Pan-Amyloid Removal Candidate AT-04 at 18th International Symposium on Amyloidosis

Sep 7, 2022 Press Releases

PDF Version AT-04 demonstrates potent binding and promotes phagocytosis in ATTR and AL amyloidosis AT-04 binds potently to Aβ, tau, and α-synuclein, common amyloid pathologies in CNS disorders such as Alzheimer’s SAN FRANCISCO, Calif. – September 7, 2022 –...

Preclinical characterization of AT-04, a pan-amyloid-binding Fc domain-peptide fusion, to serve as an opsonin for macrophage-mediated clearance of amyloid deposits

Sep 7, 2022 Posters & Publications

AUTHORS: James S. Foster1, Spencer Guthrie2, Michael L. Klein2, Gregory Bell2, Suganya Selvarajah2, Angela D. Williams1, Manasi Balachandran1, Joseph W. Jackson1, Alan Stuckey1, Emily Martin1, Sallie Macy1, D. Craig Wooliver1, R. Eric Heidel1, Stephen J. Kennel1,...

AT-03 Demonstrated Pan-amyloid Binding and Stimulated the Removal of Amyloid Deposits through Macrophage-Mediated Phagocytosis

Sep 7, 2022 Posters & Publications

AUTHORS: Christophe Sirac1, Roussine Codo1, Arnaud Jaccard1, Sébastien Bender1, Gemma Martinez Rivas1, Frank Bridoux2, Michael Klein3, Gregory Bell3, Spencer Guthrie3, Suganya Selvarajah3, Stephen J. Kennel4, Angela D. Williams4, James S. Foster4, Jonathan S. Wall4 1...