Our Pipeline
Pan-Amyloid Removal & Reversal Of The Underlying Pathology Of Systemic Amyloidosis
Making New Solutions Possible for Patients
AT ATTRALUS, WE SEE A CLEAR FUTURE WHERE MORE IS POSSIBLE FOR PATIENTS WITH SYSTEMIC AMYLOIDOSIS.
Using our proprietary pan-amyloid removal (PAR) technology, we are advancing a pipeline of novel therapeutics that remove toxic, disease-causing amyloid throughout the body with high specificity, and the potential to reverse disease pathology. We are pioneering first-in-class novel pan-amyloid therapies that bind to all types of amyloid, so that our therapies can be used for patients with all types of systemic amyloidosis and at all stages of disease.
Why It Matters
There is a critical unmet need for disease modifying therapies that can remove amyloid across all stages and types of systemic amyloidosis. The existing approved drugs for amyloidosis do not address the toxic amyloid deposits that are present and accumulate in organs and are the cause of disease burden, progressive organ failure and increased mortality in patients.
Our Pioneering Pan-Amyloid Pipeline
(1) In addition to AT-02, our pipeline of Systemic Amyloidosis therapeutics includes AT-06, a preclinical candidate that incorporates the PAR-peptide into a chimeric antigen receptor expressed in macrophages or monocytes (CAR-M), which is an alternative approach to enabling the immune system to remove amyloid deposits.
Our Pan-Amyloid Removal (PAR) Therapeutics
With the aim to treat all types of patients with systemic amyloidosis and open the door to reversing disease, at Attralus we are advancing our pipeline of product candidates for pan-amyloid removal. We have designed our novel biologics to achieve pan-amyloid removal with superior amyloid binding and immune-mediated phagocytosis.
AT-02
PAR-Peptide + IgG1 Antibody
AT-06
PAR-Peptide + CAR-M
We have an additional therapeutic candidate that incorporates differentiated technology to treat all types of systemic amyloidosis. Our preclinical therapeutic candidate AT-06 incorporates the PAR-peptide into a chimeric antigen receptor expressed in monocytes (CAR-M), which is an alternative approach to enabling the immune system to remove amyloid deposits.
Our Amyloid-Specific Imaging Agents
In support of our therapeutic strategy, we are also developing the world’s first amyloid-specific imaging agent which will improve the clinical journey for patients and dramatically expand the population of those who are diagnosed.
AT-01
Iodine (I-124) evuzamitide
PAR-Peptide + I-124
124I-evuzamitide (iodine-124 evuzamitide) utilizes the company’s pan-amyloid binding peptide as an amyloid-specific imaging agent to image all types of systemic amyloidosis by PET/CT imaging. In clinical trials, 124I-evuzamitide has been shown to detect multiple types of amyloid deposits, including AL and ATTR, in major organs such as the heart, kidney, liver, and spleen. Attralus has a special protocol assessment (SPA) in place with the FDA to conduct a single pivotal Phase 3 trial for 124I-evuzamitide.
AT-05
PAR-Peptide + 99m Tc
Our Neurodegenerative Program
Attralus is developing the next generation of therapies for neurodegenerative diseases by simultaneously targeting multiple proteinopathies. Patients suffering from neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Lewy Body diseases, often have multiple proteinopathies. The company’s research is aiming to capitalize on this by binding to multiple misfolded protein aggregates including Aβ, Tau, and α-Synuclein. Attralus’ pan-amyloid product candidates provide an opportunity for therapeutics that can simultaneously target multiple proteinopathies in individual patients unlike approved therapies that target a single proteinopathy. The company is also exploring a blood brain barrier shuttle to potentially improve brain penetration.